Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer

Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer

Abstract Inflammation can influence the development of CRC as well as immunotherapy and plays a key role in CRC. Therefore, this study aimed to investigate the potential of inflammation-related genes in CRC risk prediction. Inflammation gene models were constructed and validated by combining transcr...

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Bibliographic Details
Main Authors: Wen Yin, Yanting Ao, Qian Jia, Chao Zhang, Liping Yuan, Sha Liu, Wanmeng Xiao, Gang Luo, Xiaomin Shi, Chen Xin, Maolin Chen, Muhan Lü, Zehui Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Colorectal cancer (CRC)
Inflammation
Immune microenvironment
Molecular subtypes
Prognostic signature
Online Access:https://doi.org/10.1038/s41598-024-84998-6
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