Chorordin-like 1 inhibits pancreatic cancer cell migration and invasion: involvement of the BMP4/SMAD pathway

Chorordin-like 1 inhibits pancreatic cancer cell migration and invasion: involvement of the BMP4/SMAD pathway

IntroductionPancreatic cancer is a highly aggressive malignancy with a 6% five-year survival rate. CHRDL1, a BMP4 antagonist, has tumor-suppressive effects in breast and gastric cancers, but its role in pancreatic cancer is unclear. This study explores CHRDL1’s function and mechanism in pancreatic c...

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Bibliographic Details
Main Authors: Wei Li, Yalan Zhong, Yuqiao Song, Hongmei Wang, Zheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
CHRDL1
BMP4/SMAD
migration
invasion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1633464/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1633464/full

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