Phosphodiesterase 10A as a Therapeutic Target in Neuropsychopharmacology: A Review

Phosphodiesterase 10A as a Therapeutic Target in Neuropsychopharmacology: A Review

INTRODUCTION. Phosphodiesterases (PDEs) are enzymes that regulate intracellular signalling by catalysing the hydrolysis of cyclic nucleotides. The commercial success of selective PDE5 inhibitors for erectile dysfunction and PDE4 inhibitors for respiratory and skin diseases has drawn the close attent...

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Bibliographic Details
Main Authors: A. R. Dorotenko, I. M. Sukhanov, G. V. Iskarevskii, A. S. Ulitina, A. A. Savchenko, M. А. Tur
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2025-05-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
phosphodiesterase
pde
pde10a inhibitors
neuropsychopharmacology
pharmaceutical development
cortico-striato-thalamo-cortical circuits
Online Access:https://www.vedomostincesmp.ru/jour/article/view/723
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