Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa

Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa

IntroductionThe main obstacle to achieving an HIV-1 cure is the proviral reservoir. To promote equity in HIV cure strategies, it is crucial to study the viral reservoir of the predominant HIV-1 subtype C in both women and men. Therefore, we investigated the dynamics of the (intact) viral reservoir i...

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Main Authors: Ninée V. E. J. Buchholtz, Lucas E. Hermans, Chijioke N. Umunnakwe, Marieke M. Nühn, Regina Voss, Emma Need, Neeltje A. Kootstra, Irma Maurer, Dorien C. M. de Jong, Jori Symons, Hugo A. Tempelman, Annemarie M. J. Wensing, Monique Nijhuis
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
HIV-1 subtype B and C
IPDA
male and female
reservoir
quantification
HIV-1 transcription
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484358/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484358/full

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