Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein.

Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein.

Neisseria meningitidis is a leading cause of sepsis and meningitis. The bacterium recruits factor H (fH), a negative regulator of the complement system, to its surface via fH binding protein (fHbp), providing a mechanism to avoid complement-mediated killing. fHbp is an important antigen that elicits...

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Bibliographic Details
Main Authors: Ilse Jongerius, Hayley Lavender, Lionel Tan, Nicola Ruivo, Rachel M Exley, Joseph J E Caesar, Susan M Lea, Steven Johnson, Christoph M Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003528
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