Holistic regulation of the diabetic osteo-microenvironment via NIR-II nanocarriers with dual NO/pH responsiveness for enhanced bone regeneration

Holistic regulation of the diabetic osteo-microenvironment via NIR-II nanocarriers with dual NO/pH responsiveness for enhanced bone regeneration

Diabetic conditions impair bone regeneration due to dysregulated macrophage polarization and inflammatory imbalance. Current therapies often fail to address systemic immune homeostasis. Herein, a bone-targeted nanoplatform (abbreviated as AgSr-MSNs) is engineered to scavenge excess nitric oxide (NO)...

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Bibliographic Details
Main Authors: Xudong Xie, Junli Yang, Chong Ding, Yiming Li, Fawwaz Ai-Smadi, Kangkang Zha, Chuanlu Lin, Ze Lin, Chenyan Yu, Ruiyin Zeng, Weixian Hu, Jiewen Liao, lizhi Ouyang, Tian Xia, Peng Zhao, Bobin Mi, Guohui Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Diabetic bone regeneration
Bone microenvironment
AgSr-MSNs
Macrophages polarization
Osteogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003184
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