A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice

Objective: Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism is foundational to modern obesity pharmacotherapies. These compounds were engineered for maximal G protein alpha(s) (Gsα) signaling potency and downstream cAMP production. However, this strategy requires reconsideration as partial,...

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Main Authors: Jonathan D. Douros, Aaron Novikoff, Barent DuBois, Rebecca Rohlfs, Jacek Mokrosinski, Wouter F.J. Hogendorf, Robert Augustin, Myrte Merkestein, Lene Brandt Egaa Martini, Lars Linderoth, Elliot Gerrard, Janos Tibor Kodra, Jenny Norlin, Nikolaj Kulahin Roed, Anouk Oldenburger, Stephanie A. Mowery, Maria Waldhoer, Diego Perez-Tilve, Brian Finan, Steffen Reedtz-Runge, Timo D. Müller, Patrick J. Knerr
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Molecular Metabolism
Subjects:
GLP-1
Biased agonism
Semaglutide
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000316
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