AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression

AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression

Abstract Background Age related hearing loss (ARHL) is a sensorineural hearing disease caused by multiple factors and its pathogenesis is still unclear. This work aims to investigate the precise role of AIMP1 in ARHL. Methods HEI-OC1 cells were treated with 1 mM H2O2 for 2 h to induce cell damage. C...

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Bibliographic Details
Main Authors: Haisen Peng, Jiali Liu, Yuehui Liu, Chunhua Li, Zhilin Zhang, Shuihua Hu, Wen Xie
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Geriatrics
Subjects:
AIMP1
SIRT1
Age related hearing loss
Cuproptosis
Mitophagy
Oxidative stress
Online Access:https://doi.org/10.1186/s12877-025-06237-5
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https://doi.org/10.1186/s12877-025-06237-5

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