Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

Here, we sequenced rearranged TCRβ and TCRα chain sequences in CD4+CD8+ double positive (DP), CD4+CD8- single positive (SP4) and CD4-CD8+ (SP8) thymocyte populations from the foetus and young adult mouse. We found that life-stage had a greater impact on TCRβ and TCRα gene segment usage than cell-typ...

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Bibliographic Details
Main Authors: Jasmine Rowell, Ching-In Lau, Susan Ross, Diana C Yanez, Oscar A Peña, Benny Chain, Tessa Crompton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
thymus
TCR sequencing
TCR repertoire
repertoire selection
MHC-restriction
T-cell development
Online Access:https://elifesciences.org/articles/93493
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https://elifesciences.org/articles/93493

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