Pancreatic cancer organoids derived from EUS-guided fine needle aspiration specimens can be used to predict chemotherapy resistance

Pancreatic cancer organoids derived from EUS-guided fine needle aspiration specimens can be used to predict chemotherapy resistance

Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Although chemotherapy has become increasingly important in recent years, there are no practical markers to predict therapeutic efficacy. Here, we have aimed to identify novel markers that predict resistance to chemotherapy drugs...

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Bibliographic Details
Main Authors: Soshi Oyama, Akiko Matsuda, Ryoko Murakami, Yasuharu Kakizaki, Tetsuya Ishizawa, Toshikazu Kobayashi, Hitomi Nakamura, Yoshihito Nawa, Yu Otaki, Yamato Nagata, Soichiro Honma, Naohiko Makino, Hidenori Sato, Yoshiyuki Ueno
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Pancreatic cancer
Organoids
Drug screening
Biomarkers
Online Access:https://doi.org/10.1038/s41598-025-09395-z
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https://doi.org/10.1038/s41598-025-09395-z

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