Causal Association Between Genetically Predicted Ankle Spacing Width and Risk of Age-Related Bone Mineral Density

Causal Association Between Genetically Predicted Ankle Spacing Width and Risk of Age-Related Bone Mineral Density

Abstract While observational studies suggest associations between ankle spacing width (ASW, defined as the horizontal distance between the medial malleoli under weight-bearing conditions) and osteoporosis (OP), fractures, and falls, causal evidence remains limited. This gap hinders the translation o...

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Bibliographic Details
Main Authors: Xian-Pei Xiao, Yong-Jun Dai, Hong-Xu Li, Jun-Jie Mao, Bi-Yuan Qin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ankle spacing width
Osteoporosis
Mendelian randomization
Bone mineral density
Online Access:https://doi.org/10.1038/s41598-025-09765-7
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https://doi.org/10.1038/s41598-025-09765-7

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