Circulating tumour cells & circulating tumour DNA in patients with resectable colorectal liver metastases (MIRACLE): a prospective, observational biomarker studyResearch in context

Circulating tumour cells & circulating tumour DNA in patients with resectable colorectal liver metastases (MIRACLE): a prospective, observational biomarker studyResearch in context

Summary: Background: Recurrence risk after curative surgery for colorectal liver metastases (CRLM) remains high, underlining the need to identify prognostic markers enabling more individualised treatment approaches. Methods: In the MIRACLE, a prospective, observational biomarker study, a total of 1...

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Main Authors: Lissa Wullaert, Maurice P.H.M. Jansen, Jaco Kraan, Yannick M. Meyer, Kelly Voigt, Stavros Makrodimitris, Vanja de Weerd, Corine M. Beaufort, Mai Van, Maarten Vermaas, Eric J.T. Belt, Paul D. Gobardhan, Stefan Sleijfer, Henk M.W. Verheul, John W.M. Martens, Dirk J. Grünhagen, Saskia M. Wilting, Cornelis Verhoef, Ninos Ayez, Jan H. Wijsman, Arjen M. Rijken, Pascal Doornebosch, Joost van der Hoeven, Boris Galjart, Diederik J. Höppener, Peter M.H. Nierop, Eric P. van der Stok, Jean Helmijr, Lindsay Angus, Pauline A.J. Mendelaar, Manouk K. Bos, Elisabeth M. Jongbloed, Khrystany T. Isebia, Noortje Verschoor, Ronald van Marion, Peggy Atmodimedjo, Hendrikus J. Dubbink
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:EClinicalMedicine
Subjects:
CTC (circulating tumour cells)
ctDNA (circulating tumour DNA)
Liquid biopsy
Minimal residual disease (MRD)
Colorectal liver metastases (CRLM)
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003384
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