Detection of Mycobacterium tuberculosis from tongue swabs using sonication and sequence-specific hybridization capture.

Tongue swabs hold promise as a non-invasive sample for diagnosing tuberculosis (TB). However, their utility as replacements for sputum has been limited by their varied diagnostic performance in PCR assays compared to sputum. The use of silica-based DNA extraction methods may limit sensitivity due to...

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Bibliographic Details
Main Authors: Alexander J Yan, Alaina M Olson, Kris M Weigel, Angelique K Luabeya, Erin Heiniger, Mark Hatherill, Gerard A Cangelosi, Paul Yager
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0308235
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