Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion

Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion

Porcine epidemic diarrhea virus (PEDV) induces enteritis and diarrhea in piglets. Mitochondrial DNA (mtDNA) contributes to virus-induced inflammatory responses; however, the involvement of inflammasomes in PEDV infection responses remains unclear. We investigated the mechanism underlying inflammasom...

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Bibliographic Details
Main Authors: Di Bao, Shushuai Yi, Luobing Zhao, Han Zhao, Jiuyuan Liu, Yiming Wei, Guixue Hu, Xinxin Liu
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Veterinary Sciences
Subjects:
PEDV
mtDNA
NLRP3
IPEC-J2
IL-1β
inflammation
Online Access:https://www.mdpi.com/2306-7381/11/12/643
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