Discovery of drug transporter inhibitors tied to long noncoding RNA in resistant cancer cells; a computational model -in silico- study

Discovery of drug transporter inhibitors tied to long noncoding RNA in resistant cancer cells; a computational model -in silico- study

Chemotherapeutic resistance is a major obstacle to chemotherapeutic failure. Cancer cell resistance involves several mechanisms, including epithelial-to-mesenchymal transition (EMT), signaling pathway bypass, drug efflux activation, and impairment of drug entry. P-glycoproteins (P-gp) are an efflux...

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Bibliographic Details
Main Authors: Mohanad Diab, Amel Hamdi, Feras Al-Obeidat, Wael Hafez, Ivan Cherrez-Ojeda, Muneir Gador, Gowhar Rashid, Sana F. Elkhazin, Mahmad Anwar Ibrahim, Tarek Farag Ismail, Samar Sami Alkafaas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
chemoresistance
p-glycoprotein-1
lncRNA
efflux transporters
in silico analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1511029/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1511029/full

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