The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants
The constant mutation of SARS-CoV-2 has led to the continuous appearance of viral variants and their pandemics and has improved the development of vaccines with a broad spectrum of antigens to curb the spread of the virus. The work described here suggested a novel vaccine with a virus-like structure...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2473183 |
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| author | Jingjing Zhang Fengyuan Zeng Yanmei Li Changyong Mu Change Liu Lichun Wang Xiaowu Peng Liping He Yanrui Su Hongbing Li An Wang Lin Feng Dongxiu Gao Zhixiao Zhang Gang Xu Yixuan Wang Rong Yue Junbo Si Lichun Zheng Xiong Zhang Fuyun He Hongkun Yi Zhongshu Tang Gaocan Li Kaili Ma Qihan Li |
| author_facet | Jingjing Zhang Fengyuan Zeng Yanmei Li Changyong Mu Change Liu Lichun Wang Xiaowu Peng Liping He Yanrui Su Hongbing Li An Wang Lin Feng Dongxiu Gao Zhixiao Zhang Gang Xu Yixuan Wang Rong Yue Junbo Si Lichun Zheng Xiong Zhang Fuyun He Hongkun Yi Zhongshu Tang Gaocan Li Kaili Ma Qihan Li |
| author_sort | Jingjing Zhang |
| collection | DOAJ |
| description | The constant mutation of SARS-CoV-2 has led to the continuous appearance of viral variants and their pandemics and has improved the development of vaccines with a broad spectrum of antigens to curb the spread of the virus. The work described here suggested a novel vaccine with a virus-like structure (VLS) composed of combined mRNA and protein that is capable of stimulating the immune system in a manner similar to that of viral infection. This VLS vaccine is characterized by its ability to specifically target dendritic cells and/or macrophages through S1 protein recognition of the DC-SIGN receptor in cells, which leads to direct mRNA delivery to these innate immune cells for activation of robust immunity with a broad spectrum of neutralizing antibodies and immune protective capacity against variants. Research on its composition characteristics and structural features has suggested its druggability. Compared with the current mRNA vaccine, the VLS vaccine was identified as having no cytotoxicity at its effective application dosage, while the results of safety observations in animals revealed fewer adverse reactions during immunization. |
| format | Article |
| id | doaj-art-c9b633e7bf1e40a7bee3e122b70d7cb6 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-c9b633e7bf1e40a7bee3e122b70d7cb62025-08-20T03:48:14ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2473183The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variantsJingjing Zhang0Fengyuan Zeng1Yanmei Li2Changyong Mu3Change Liu4Lichun Wang5Xiaowu Peng6Liping He7Yanrui Su8Hongbing Li9An Wang10Lin Feng11Dongxiu Gao12Zhixiao Zhang13Gang Xu14Yixuan Wang15Rong Yue16Junbo Si17Lichun Zheng18Xiong Zhang19Fuyun He20Hongkun Yi21Zhongshu Tang22Gaocan Li23Kaili Ma24Qihan Li25Weirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaWeirui Biotechnology (Kunming) Co. Ltd, Ciba Biotechnology Innovation Center, Kunming, Yunnan, ChinaThe constant mutation of SARS-CoV-2 has led to the continuous appearance of viral variants and their pandemics and has improved the development of vaccines with a broad spectrum of antigens to curb the spread of the virus. The work described here suggested a novel vaccine with a virus-like structure (VLS) composed of combined mRNA and protein that is capable of stimulating the immune system in a manner similar to that of viral infection. This VLS vaccine is characterized by its ability to specifically target dendritic cells and/or macrophages through S1 protein recognition of the DC-SIGN receptor in cells, which leads to direct mRNA delivery to these innate immune cells for activation of robust immunity with a broad spectrum of neutralizing antibodies and immune protective capacity against variants. Research on its composition characteristics and structural features has suggested its druggability. Compared with the current mRNA vaccine, the VLS vaccine was identified as having no cytotoxicity at its effective application dosage, while the results of safety observations in animals revealed fewer adverse reactions during immunization.https://www.tandfonline.com/doi/10.1080/21645515.2025.2473183Virus-like structureimmunitymRNA vaccinedosage |
| spellingShingle | Jingjing Zhang Fengyuan Zeng Yanmei Li Changyong Mu Change Liu Lichun Wang Xiaowu Peng Liping He Yanrui Su Hongbing Li An Wang Lin Feng Dongxiu Gao Zhixiao Zhang Gang Xu Yixuan Wang Rong Yue Junbo Si Lichun Zheng Xiong Zhang Fuyun He Hongkun Yi Zhongshu Tang Gaocan Li Kaili Ma Qihan Li The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants Human Vaccines & Immunotherapeutics Virus-like structure immunity mRNA vaccine dosage |
| title | The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants |
| title_full | The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants |
| title_fullStr | The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants |
| title_full_unstemmed | The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants |
| title_short | The characterization of technical design of a virus-like structure (VLS) nanodelivery system as vaccine candidate against SARS-CoV-2 variants |
| title_sort | characterization of technical design of a virus like structure vls nanodelivery system as vaccine candidate against sars cov 2 variants |
| topic | Virus-like structure immunity mRNA vaccine dosage |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2473183 |
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