Estrogen replacement therapy reverses spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of lead-exposed ovariectomized Wistar rats

Background: Although menopause is a component of chronological aging, it may be induced by exposure to heavy metals like lead. Interestingly, lead exposure, just like the postmenopausal state, has been associated with spatial memory loss and neurodegeneration; however, the impact of hormone replacem...

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Bibliographic Details
Main Authors: Abiodun Shukrat Lasisi-Sholola, Sodiq Opeyemi Hammed, Richard Adedamola Ajike, Roland Eghoghosoa Akhigbe, Oladele Ayobami Afolabi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Toxicology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000537
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