The role of intestinal microbiota in the humoral response to SARS-CoV-2 after mRNA-1273 vaccination

The role of intestinal microbiota in the humoral response to SARS-CoV-2 after mRNA-1273 vaccination

Abstract The gut microbiota plays a key role in shaping immune responses, including those induced by vaccination. Its impact on the humoral response to mRNA-based SARS-CoV-2 vaccines, however, remains underexplored. We analyzed gut microbiota composition and anti-Spike (S) IgG levels in 50 healthcar...

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Main Authors: María Tarriño, Juan Francisco Gutiérrez-Bautista, María José Olivares Durán, Abel Garcia-Diaz, Antonio José Cabrera-Serrano, Juan Sainz, Fernando Cobo, Teresa Rodriguez, Juan Antonio Reguera, Mónica Bernal, Miguel Ángel López-Nevot, Antonio Sampedro
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gut microbiota
MRNA-1273
SARS-CoV-2 vaccination
Microbiome and immunity
16S rRNA sequencing
Bacterial taxa and immunogenicity
Online Access:https://doi.org/10.1038/s41598-025-11103-w
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https://doi.org/10.1038/s41598-025-11103-w

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