Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells
Different physicochemical factors, such as size, concentration, shape, exposure time, area, and surface chemistry, influence the interaction between metallic nanoparticles (MNPs) and immune system cells. Particle size is particularly significant, as smaller particles facilitate easier cell internali...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nanotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2024.1496230/full |
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| author | Sinai G. Gutiérrez-Cruz Alejandro Muñoz-Diosdado Ramón A. Gutiérrez-Calleja Octavio Rodríguez-Cortés Ana E. Ortiz-Reyez Raúl Flores-Mejía |
| author_facet | Sinai G. Gutiérrez-Cruz Alejandro Muñoz-Diosdado Ramón A. Gutiérrez-Calleja Octavio Rodríguez-Cortés Ana E. Ortiz-Reyez Raúl Flores-Mejía |
| author_sort | Sinai G. Gutiérrez-Cruz |
| collection | DOAJ |
| description | Different physicochemical factors, such as size, concentration, shape, exposure time, area, and surface chemistry, influence the interaction between metallic nanoparticles (MNPs) and immune system cells. Particle size is particularly significant, as smaller particles facilitate easier cell internalization, while larger particles exhibit lower immunogenicity. Concentration also plays a critical role; high concentrations may trigger toxic responses, while low concentrations may act beneficially. Additionally, the morphology of nanoparticles affects their affinity for different cell types. It modulates the intensity of immune responses, while exposure time determines whether the immune response manifests as acute or chronic. The material composition of nanoparticles influences the initial interaction with cells, including protein adsorption and recognition by cell receptors. Understanding and controlling physicochemical factors is essential for developing therapeutic applications based on MNPs and minimizing potential adverse effects on the immune system. This paper reviews the reported biological effects of MNPs on various immune cell types, including B and T lymphocytes, neutrophils, monocytes, macrophages, dendritic cells, natural killer cells, mast cells, basophils, and eosinophils. |
| format | Article |
| id | doaj-art-c980322d95b94c7899ec722ddcb7a6a2 |
| institution | Kabale University |
| issn | 2673-3013 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj-art-c980322d95b94c7899ec722ddcb7a6a22025-01-07T06:45:28ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132025-01-01610.3389/fnano.2024.14962301496230Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cellsSinai G. Gutiérrez-Cruz0Alejandro Muñoz-Diosdado1Ramón A. Gutiérrez-Calleja2Octavio Rodríguez-Cortés3Ana E. Ortiz-Reyez4Raúl Flores-Mejía5Departamento de Ciencias Básicas, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, MexicoDepartamento de Ciencias Básicas, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, MexicoDepartamento de Ciencias Básicas, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, MexicoLaboratorio de Inflamación y Obesidad, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, MexicoLaboratorio de Células Troncales Tumorales, UIMEO, Hospital Centro Médico Nacional Siglo XXI, IMSS, Mexico, MexicoLaboratorio de Inflamación y Obesidad, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, MexicoDifferent physicochemical factors, such as size, concentration, shape, exposure time, area, and surface chemistry, influence the interaction between metallic nanoparticles (MNPs) and immune system cells. Particle size is particularly significant, as smaller particles facilitate easier cell internalization, while larger particles exhibit lower immunogenicity. Concentration also plays a critical role; high concentrations may trigger toxic responses, while low concentrations may act beneficially. Additionally, the morphology of nanoparticles affects their affinity for different cell types. It modulates the intensity of immune responses, while exposure time determines whether the immune response manifests as acute or chronic. The material composition of nanoparticles influences the initial interaction with cells, including protein adsorption and recognition by cell receptors. Understanding and controlling physicochemical factors is essential for developing therapeutic applications based on MNPs and minimizing potential adverse effects on the immune system. This paper reviews the reported biological effects of MNPs on various immune cell types, including B and T lymphocytes, neutrophils, monocytes, macrophages, dendritic cells, natural killer cells, mast cells, basophils, and eosinophils.https://www.frontiersin.org/articles/10.3389/fnano.2024.1496230/fullmetallic nanoparticlescell interactionimmunological compatibilityphysicochemical factorsimmune system cells |
| spellingShingle | Sinai G. Gutiérrez-Cruz Alejandro Muñoz-Diosdado Ramón A. Gutiérrez-Calleja Octavio Rodríguez-Cortés Ana E. Ortiz-Reyez Raúl Flores-Mejía Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells Frontiers in Nanotechnology metallic nanoparticles cell interaction immunological compatibility physicochemical factors immune system cells |
| title | Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells |
| title_full | Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells |
| title_fullStr | Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells |
| title_full_unstemmed | Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells |
| title_short | Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells |
| title_sort | influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells |
| topic | metallic nanoparticles cell interaction immunological compatibility physicochemical factors immune system cells |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2024.1496230/full |
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