Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

Abstract Large‐scale proteomic approaches have been used to study signaling pathways. However, identification of biologically relevant hits from a single screen remains challenging due to limitations inherent in each individual approach. To overcome these limitations, we implemented an integrated, m...

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Bibliographic Details
Main Authors: Bryan W Miller, Garnet Lau, Chris Grouios, Emanuela Mollica, Miriam Barrios‐Rodiles, Yongmei Liu, Alessandro Datti, Quaid Morris, Jeffrey L Wrana, Liliana Attisano
Format: Article
Language:English
Published: Springer Nature 2009-10-01
Series:Molecular Systems Biology
Subjects:
cancer biology
signal transduction
systems biology
Online Access:https://doi.org/10.1038/msb.2009.72
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https://doi.org/10.1038/msb.2009.72

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