Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy

Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy

The orphan nuclear receptor Nur77 is emerging as an attractive target for cancer therapy, and activating Nur77's non-genotypic anticancer function has demonstrated strong therapeutic potential. However, few Nur77 site B ligands have been identified as excellent anticancer compounds. There are n...

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Bibliographic Details
Main Authors: Jun Chen, Taige Zhao, Wenbin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiaoya Chen, Yingkun Qiu, Xiumin Wang, Zhen Wu, Tianwei Lin, Baicun Li, Xueqin Chen, Meijuan Fang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Novel Nur77 ligand
4,4′-Bipyridine cinnamamide derivatives
X-ray crystallography
Nur77/Bcl-2 apoptotic pathway
Anticancer activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524002867
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