Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report

Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report

Abstract Background Trastuzumab (T-mab)-based chemotherapy is a standard regimen for human epithelial growth factor 2 (HER2)-positive gastric cancer. However, some patients have demonstrated a change in HER2 status after T-mab-based treatment of breast cancer. We report a rare case of mixed adenoneu...

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Main Authors: Hiromi Nagata, Hironori Tsujimoto, Yoshihisa Yaguchi, Keita Kouzu, Yujiro Itazaki, Yusuke Ishibashi, Satoshi Tsuchiya, Takao Sugihara, Nozomi Ito, Manabu Harada, Shinsuke Nomura, Yoshitaka Utsumi, Hideyuki Shimazaki, Yoji Kishi, Hideki Ueno
Format: Article
Language:English
Published: Japan Surgical Society 2020-01-01
Series:Surgical Case Reports
Subjects:
Trastuzumab-based chemotherapy
Gastric cancer
Conversion surgery
Liver metastasis
Prognosis
Online Access:https://doi.org/10.1186/s40792-020-0774-7
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https://doi.org/10.1186/s40792-020-0774-7

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