Reactive oxygen species responsive nanomotors for gene edited metabolic disruption and immunotherapy

Reactive oxygen species responsive nanomotors for gene edited metabolic disruption and immunotherapy

Abstract While gene-editing-based tumor therapy holds promise, conventional passive-diffusion vectors face limited penetration in dense solid tumors. Here, we developed a ROS-driven gene editing nanomotor (RDN@PL), which takes hemin as the core and encapsulates CRISPR/Cas9 plasmids targeting LDHA (A...

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Bibliographic Details
Main Authors: Zhiyong Liu, Xiaowei Luan, Qianglan Lu, Shurong Qin, Fei Zeng, Zhi Li, Bangshun He, Yujun Song
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59590-9
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