Assessment of cognitive impairment in Tunisian hypertensive patients
BACKGROUND: The prevention of cognitive impairment is a major public health issue. Several international studies have shown a significant association between arterial hypertension (AH) and cognitive decline, highlighting the role of AH as a risk factor for dementia. Our aim was to evaluate cognitive...
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| Format: | Article |
| Language: | English |
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Via Medica
2025-04-01
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| Series: | Arterial Hypertension |
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| Online Access: | https://journals.viamedica.pl/arterial_hypertension/article/view/100152 |
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| author | Syrine Saidane Ahlem Khannouch Hakim Lamine Ihsen Zairi Khadija Mzoughi Sondes Kraiem |
| author_facet | Syrine Saidane Ahlem Khannouch Hakim Lamine Ihsen Zairi Khadija Mzoughi Sondes Kraiem |
| author_sort | Syrine Saidane |
| collection | DOAJ |
| description | BACKGROUND: The prevention of cognitive impairment is a major public health issue. Several international studies have shown a significant association between arterial hypertension (AH) and cognitive decline, highlighting the role of AH as a risk factor for dementia. Our aim was to evaluate cognitive impairment in hypertensive patients. MATERIAL AND METHODS: We conducted a descriptive, prospective, multicenter study involving patients over 40 years old with confirmed essential hypertension for more than 3 years. All participants underwent neuropsychological assessment using three tests exploring cognitive function: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Memory and Executive Screening (MES). Then, we divided our population into two groups: a group with cognitive decline defined by an MMSE score < 24 and no cognitive decline. RESULTS: We included 200 patients with a mean age of 65 ± 9 years and a gender ratio of 0.78. Assessment of cognitive performance revealed a cognitive decline in 42.5% of patients (n = 85) by MMSE, 73.5% of cases (n = 147) by MoCA, and 82.5% of cases (n = 165) by MES. The four factors independently predictive of cognitive decline were: age [odds ratio (OR) adjusted: 10.6, 95% confidence interval (CI): 4.38–23.57], p < 0.001), female sex (OR adjusted: 7.81, 95% CI: 3.15–19.29, p < 0.001), sedentary lifestyle (OR adjusted: 2,52, 95% CI: 1.09–5.86, p = 0.031) and poor blood pressure (BP) control (OR adjusted: 3.33, 95% CI: 1.35–5.86, p = 0.009). CONCLUSION: Our study showed that cognitive impairment was frequent in hypertensive patients. Screening should be carried out to implement an appropriate therapeutic strategy. |
| format | Article |
| id | doaj-art-c851a93257bd4ed8be720e8fbb625e17 |
| institution | Kabale University |
| issn | 2449-6170 2449-6162 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Arterial Hypertension |
| spelling | doaj-art-c851a93257bd4ed8be720e8fbb625e172025-08-21T06:08:33ZengVia MedicaArterial Hypertension2449-61702449-61622025-04-0129Continuous Publishing10.5603/ah.100152Assessment of cognitive impairment in Tunisian hypertensive patientsSyrine Saidane0Ahlem Khannouch1Hakim Lamine2Ihsen Zairi3Khadija Mzoughi4Sondes Kraiem5Cardiology Department, Habib Bougatfa Hospital, Faculty of Medicine de Tunis, Tunis El Manar University, Tunis, TunisiaCardiology Department, Habib Thameur Hospital, Faculty of Medicine de Tunis, Tunis El Manar University, Tunis, TunisiaCardiology Department, Habib Thameur Hospital, Faculty of Medicine de Tunis, Tunis El Manar University, Tunis, TunisiaCardiology Department, Habib Thameur Hospital, Faculty of Medicine de Tunis, Tunis El Manar University, Tunis, TunisiaCardiology Department, Habib Bougatfa Hospital, Faculty of Medicine de Tunis, Tunis El Manar University, Tunis, TunisiaCardiology Department, Habib Bougatfa Hospital, Faculty of Medicine de Tunis, Tunis El Manar University, Tunis, TunisiaBACKGROUND: The prevention of cognitive impairment is a major public health issue. Several international studies have shown a significant association between arterial hypertension (AH) and cognitive decline, highlighting the role of AH as a risk factor for dementia. Our aim was to evaluate cognitive impairment in hypertensive patients. MATERIAL AND METHODS: We conducted a descriptive, prospective, multicenter study involving patients over 40 years old with confirmed essential hypertension for more than 3 years. All participants underwent neuropsychological assessment using three tests exploring cognitive function: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Memory and Executive Screening (MES). Then, we divided our population into two groups: a group with cognitive decline defined by an MMSE score < 24 and no cognitive decline. RESULTS: We included 200 patients with a mean age of 65 ± 9 years and a gender ratio of 0.78. Assessment of cognitive performance revealed a cognitive decline in 42.5% of patients (n = 85) by MMSE, 73.5% of cases (n = 147) by MoCA, and 82.5% of cases (n = 165) by MES. The four factors independently predictive of cognitive decline were: age [odds ratio (OR) adjusted: 10.6, 95% confidence interval (CI): 4.38–23.57], p < 0.001), female sex (OR adjusted: 7.81, 95% CI: 3.15–19.29, p < 0.001), sedentary lifestyle (OR adjusted: 2,52, 95% CI: 1.09–5.86, p = 0.031) and poor blood pressure (BP) control (OR adjusted: 3.33, 95% CI: 1.35–5.86, p = 0.009). CONCLUSION: Our study showed that cognitive impairment was frequent in hypertensive patients. Screening should be carried out to implement an appropriate therapeutic strategy.https://journals.viamedica.pl/arterial_hypertension/article/view/100152hypertensioncognitive impairmentdementiatreatment |
| spellingShingle | Syrine Saidane Ahlem Khannouch Hakim Lamine Ihsen Zairi Khadija Mzoughi Sondes Kraiem Assessment of cognitive impairment in Tunisian hypertensive patients Arterial Hypertension hypertension cognitive impairment dementia treatment |
| title | Assessment of cognitive impairment in Tunisian hypertensive patients |
| title_full | Assessment of cognitive impairment in Tunisian hypertensive patients |
| title_fullStr | Assessment of cognitive impairment in Tunisian hypertensive patients |
| title_full_unstemmed | Assessment of cognitive impairment in Tunisian hypertensive patients |
| title_short | Assessment of cognitive impairment in Tunisian hypertensive patients |
| title_sort | assessment of cognitive impairment in tunisian hypertensive patients |
| topic | hypertension cognitive impairment dementia treatment |
| url | https://journals.viamedica.pl/arterial_hypertension/article/view/100152 |
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