Astragalin improved mitochondrial function through AMPK/PGC-1α pathway and alleviated renal injury in diabetic nephropathy

Astragalin improved mitochondrial function through AMPK/PGC-1α pathway and alleviated renal injury in diabetic nephropathy

Objective To explore the effect and mechanism of astragalin （AG） in alleviating renal injury in diabetic kidney disease(DKD). Methods db/m and db/db mice aged 16 weeks were randomized into four groups of db/m, db/m+AG （5 mg/kg）, db/db and db/db+AG （5 mg/kg）. Primary Human renal cortex proximal convo...

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Bibliographic Details
Main Authors: Yi Luo, Meng-jing Wang, Shu-fen Liu, Shuang Yuan, Hao Huang
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2024-11-01
Series:Linchuang shenzangbing zazhi
Subjects:
astragalin
diabetic kidney disease
adenosine monophosphate-activated protein kinase
peroxisome proliferator-activated receptor γ coactivator-1α
Online Access:http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.11.007
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http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.11.007

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