DET induces apoptosis and suppresses tumor invasion in glioma cells via PI3K/AKT pathway

DET induces apoptosis and suppresses tumor invasion in glioma cells via PI3K/AKT pathway

IntroductionGliomas, particularly glioblastomas (GBM), are highly aggressive with a poor prognosis and low survival rate. Currently, deoxyelephantopin (DET) has shown promising anti-inflammatory and anti-tumor effects. Using clinical prognostic analysis, molecular docking, and network pharmacology,...

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Bibliographic Details
Main Authors: Rui Zhao, Mengran Wang, Zeyu Wu, Panpan Zhao, Huiling Dong, Yue Su, Chenghui Zhao, Min Qi, Shizhang Ling, Xiaochun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
glioma
cell proliferation
cell apoptosis
Pl3K
cell invasion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1528454/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1528454/full

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