Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure
ObjectiveTo investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters in patients with early-onset pos...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1490316/full |
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| author | Le Zhou Mingyuan Niu Wei Chen Qian Hu Yi Chen Xiaohong Geng Jiani Gu |
| author_facet | Le Zhou Mingyuan Niu Wei Chen Qian Hu Yi Chen Xiaohong Geng Jiani Gu |
| author_sort | Le Zhou |
| collection | DOAJ |
| description | ObjectiveTo investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters in patients with early-onset post-myocardial infarction heart failure (HF).MethodsA total of 98 patients with early-onset post-myocardial infarction HF were enrolled and randomly divided into a control group (n = 48, receiving standard therapy) and an observation group (n = 50, receiving standard therapy plus dapagliflozin 10 mg daily). HRV, cardiac function, and echocardiographic parameters were measured at baseline and after 24 weeks of treatment. Short-term prognosis and adverse events were also monitored.ResultsCompared with the control group, the observation group showed significantly greater improvements in SDNN and SDANN (P < 0.05). Significant improvements were also observed in sST2 and NT-proBNP levels in the observation group compared to the control group (P < 0.05). Additionally, echocardiographic parameters, including EF, LVESD, LVEDD, IVST, LVMI, and E/e’, showed greater improvement in the observation group (P < 0.05). The incidence of major adverse cardiovascular events was lower in the observation group (P < 0.05). Multivariate logistic regression model revealed that dapagliflozin use was independently associated with a reduced risk of MACE (OR = 0.265, 95% CI: 0.097–0.724, P = 0.010).ConclusionEarly administration of dapagliflozin 10 mg, in addition to standard therapy, can improve autonomic function, cardiac function, and short-term prognosis in patients with early-onset post-myocardial infarction heart failure. |
| format | Article |
| id | doaj-art-c7f5003d8e1d418d85f3e66808118949 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-c7f5003d8e1d418d85f3e668081189492025-01-06T06:59:10ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14903161490316Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failureLe Zhou0Mingyuan Niu1Wei Chen2Qian Hu3Yi Chen4Xiaohong Geng5Jiani Gu6Department of Cardiology, Shibei Hospital of Jing'an District, Shanghai, ChinaDepartment of Cardiology, Shigatse People’s Hospital, Xizang, ChinaDepartment of Cardiology, Zhabei Central Hospital of Jing’an District, Shanghai, ChinaDepartment of Cardiology, Shibei Hospital of Jing'an District, Shanghai, ChinaDepartment of Cardiology, Shibei Hospital of Jing'an District, Shanghai, ChinaDepartment of Cardiology, Shibei Hospital of Jing'an District, Shanghai, ChinaDepartment of Cardiology, Shibei Hospital of Jing'an District, Shanghai, ChinaObjectiveTo investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters in patients with early-onset post-myocardial infarction heart failure (HF).MethodsA total of 98 patients with early-onset post-myocardial infarction HF were enrolled and randomly divided into a control group (n = 48, receiving standard therapy) and an observation group (n = 50, receiving standard therapy plus dapagliflozin 10 mg daily). HRV, cardiac function, and echocardiographic parameters were measured at baseline and after 24 weeks of treatment. Short-term prognosis and adverse events were also monitored.ResultsCompared with the control group, the observation group showed significantly greater improvements in SDNN and SDANN (P < 0.05). Significant improvements were also observed in sST2 and NT-proBNP levels in the observation group compared to the control group (P < 0.05). Additionally, echocardiographic parameters, including EF, LVESD, LVEDD, IVST, LVMI, and E/e’, showed greater improvement in the observation group (P < 0.05). The incidence of major adverse cardiovascular events was lower in the observation group (P < 0.05). Multivariate logistic regression model revealed that dapagliflozin use was independently associated with a reduced risk of MACE (OR = 0.265, 95% CI: 0.097–0.724, P = 0.010).ConclusionEarly administration of dapagliflozin 10 mg, in addition to standard therapy, can improve autonomic function, cardiac function, and short-term prognosis in patients with early-onset post-myocardial infarction heart failure.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1490316/fulldapagliflozinacute myocardial infarctionheart rate variabilitysoluble growth stimulation expressed gene 2 proteinN-terminal pro B-type natriuretic peptide |
| spellingShingle | Le Zhou Mingyuan Niu Wei Chen Qian Hu Yi Chen Xiaohong Geng Jiani Gu Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure Frontiers in Cardiovascular Medicine dapagliflozin acute myocardial infarction heart rate variability soluble growth stimulation expressed gene 2 protein N-terminal pro B-type natriuretic peptide |
| title | Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure |
| title_full | Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure |
| title_fullStr | Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure |
| title_full_unstemmed | Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure |
| title_short | Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure |
| title_sort | effects of dapagliflozin on heart rate variability cardiac function and short term prognosis in early onset post myocardial infarction heart failure |
| topic | dapagliflozin acute myocardial infarction heart rate variability soluble growth stimulation expressed gene 2 protein N-terminal pro B-type natriuretic peptide |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1490316/full |
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