Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study

Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study

Background and purpose: Breast cancer is the second cause of mortality among women. HER2, a member of the epidermal growth factor receptor family, is overexpressed in approximately 25% of breast cancer cases. This receptor represents a valuable therapeutic target in the management of breast cancer....

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Main Authors: Zeinab Ghesmati, Khadijeh Ahmadi, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Seyyed Hossein Khatami, Hasan Ghasemi, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour
Format: Article
Language:English
Published: Mazandaran University of Medical Sciences 2025-05-01
Series:Journal of Mazandaran University of Medical Sciences
Subjects:
breast cancer
shiga-like toxin 2 subunit a
herceptin
her2
bioinformatics
immunotoxin
Online Access:http://jmums.mazums.ac.ir/article-1-21452-en.pdf
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http://jmums.mazums.ac.ir/article-1-21452-en.pdf

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