Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation

Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation

Abstract Background MED12 is a key regulator of transcription and chromatin architecture, essential for normal hematopoiesis. While its dysregulation has been implicated in hematological malignancies, the mechanisms driving its upregulation in acute myeloid leukemia (AML) remain poorly understood. W...

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Bibliographic Details
Main Authors: Arundhati Chavan, Cassidy Jones, Whit Lawrence, Samrat Roy Choudhury
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Epigenetics & Chromatin
Subjects:
MED12
DNA methylation
Enhancer
Acute myeloid leukemia
Online Access:https://doi.org/10.1186/s13072-025-00610-9
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