An arginine switch drives the stepwise activation of β-arrestin by CXCR7.

An arginine switch drives the stepwise activation of β-arrestin by CXCR7.

β-arrestins (βarrs) play a crucial role in regulating G protein-coupled receptor (GPCR) signaling and trafficking. Canonically, interactions of βarr with the phosphorylated intracellular GPCR-tail induce a multi-step conformational transition that results in the activation of βarr. Depending on the...

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Main Authors: Jeong Seok Ji, Yaejin Yun, Tomasz Maciej Stepniewski, Hye-Jin Yoon, Kyungjin Min, Ji Young Park, Chiwoon Chung, Miguel Dieguez Eceolaza, Ka Young Chung, Jana Selent, Hyung Ho Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003312
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https://doi.org/10.1371/journal.pbio.3003312

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