METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer

METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer

Abstract Background Colorectal cancer (CRC) is characterized by poor responsiveness to immune evasion and immunotherapy. RNA 7-methylguanine (m7G) modification plays a key role in tumorigenesis. However, the mechanisms by which m7G-modified RNA metabolism affects tumor progression are not fully unde...

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Bibliographic Details
Main Authors: Fang Wang, Chen Yang, Fang Zheng, Yang Yan, Guifang Li, Yanyan Feng, Hejia Xu, Zilong He, Dongyan Cai, Hairong Sun, Xiaowei Qi, Yong Mao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
M7G methylation
METTL1
PKM2
H3K9la
Colorectal cancer
Immune evasion
Online Access:https://doi.org/10.1186/s12967-024-05991-1
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