WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study
Abstract Background Different left atrial appendage closure (LAAC) devices have been introduced into the clinical setting. A new dual-seal mechanism LACbes® occluder with isogenous barbs for LAAC has been designed to facilitate easier delivery and improve safety. The purpose of this study is to comp...
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BMC
2025-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04383-z |
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| author | Song Zhang Sihuai Xiong Sha Zhang Keyu Chen Hua Wang Ke Li Xudong Xu Xianxian Zhao Ni Zhu Xinmiao Huang Yongwen Qin Zhifu Guo Yuan Bai |
| author_facet | Song Zhang Sihuai Xiong Sha Zhang Keyu Chen Hua Wang Ke Li Xudong Xu Xianxian Zhao Ni Zhu Xinmiao Huang Yongwen Qin Zhifu Guo Yuan Bai |
| author_sort | Song Zhang |
| collection | DOAJ |
| description | Abstract Background Different left atrial appendage closure (LAAC) devices have been introduced into the clinical setting. A new dual-seal mechanism LACbes® occluder with isogenous barbs for LAAC has been designed to facilitate easier delivery and improve safety. The purpose of this study is to compare the clinical outcomes of the WATCHMAN with those of the LACbes® device for LAAC. Methods Consecutive patients with atrial fibrillation (AF) who had undergone LAAC performed using a WATCHMAN or LACbes® device from June 2016 to February 2022 were included. The primary efficacy endpoint included ischemic stroke, cardiovascular/unexplained death and device-related thrombus, while the primary safety endpoint included major peri-procedural complications and major bleeding events during clinical follow-ups. 1:1 propensity score matching (PSM) was performed. Results After PSM, 184 patients were included in each group. The mean CHA2DS2-VASc score was 3.1 ± 1.5 (LACbes®) vs. 3.1 ± 1.4 (WATCHMAN), and the HAS-BLED score was 2.7 ± 1.1 vs. 2.7 ± 1.0. At a mean follow-up of 2.5 ± 1.5 vs. 2.4 ± 0.9 years, the defined three endpoints were comparable between the two groups. The occurrence of all-cause stroke was lower in 5/452 (1.8%) with LACbes® vs. 16/433 (3.7%) with WATCHMAN occluders (HR, 0.40, 95% confidence interval (CI), 0.18–0.89, P = 0.023), and the incidence of any bleeding was higher in the WATCHMAN group (41/433, 9.5% vs. 8/452, 1.8%; HR, 0.19, 95% CI, 0.11–0.33). Conclusion The LACbes® occluder exhibited comparable safety and efficacy of stroke prevention for AF when compared with the WATCHMAN device. |
| format | Article |
| id | doaj-art-c7887368ead544378acc3cdc81980906 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-c7887368ead544378acc3cdc819809062025-01-12T12:07:24ZengBMCBMC Cardiovascular Disorders1471-22612025-01-0125111110.1186/s12872-024-04383-zWATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched studySong Zhang0Sihuai Xiong1Sha Zhang2Keyu Chen3Hua Wang4Ke Li5Xudong Xu6Xianxian Zhao7Ni Zhu8Xinmiao Huang9Yongwen Qin10Zhifu Guo11Yuan Bai12Department of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityDepartment of Cardiology, Changhai Hospital, Naval Medical UniversityAbstract Background Different left atrial appendage closure (LAAC) devices have been introduced into the clinical setting. A new dual-seal mechanism LACbes® occluder with isogenous barbs for LAAC has been designed to facilitate easier delivery and improve safety. The purpose of this study is to compare the clinical outcomes of the WATCHMAN with those of the LACbes® device for LAAC. Methods Consecutive patients with atrial fibrillation (AF) who had undergone LAAC performed using a WATCHMAN or LACbes® device from June 2016 to February 2022 were included. The primary efficacy endpoint included ischemic stroke, cardiovascular/unexplained death and device-related thrombus, while the primary safety endpoint included major peri-procedural complications and major bleeding events during clinical follow-ups. 1:1 propensity score matching (PSM) was performed. Results After PSM, 184 patients were included in each group. The mean CHA2DS2-VASc score was 3.1 ± 1.5 (LACbes®) vs. 3.1 ± 1.4 (WATCHMAN), and the HAS-BLED score was 2.7 ± 1.1 vs. 2.7 ± 1.0. At a mean follow-up of 2.5 ± 1.5 vs. 2.4 ± 0.9 years, the defined three endpoints were comparable between the two groups. The occurrence of all-cause stroke was lower in 5/452 (1.8%) with LACbes® vs. 16/433 (3.7%) with WATCHMAN occluders (HR, 0.40, 95% confidence interval (CI), 0.18–0.89, P = 0.023), and the incidence of any bleeding was higher in the WATCHMAN group (41/433, 9.5% vs. 8/452, 1.8%; HR, 0.19, 95% CI, 0.11–0.33). Conclusion The LACbes® occluder exhibited comparable safety and efficacy of stroke prevention for AF when compared with the WATCHMAN device.https://doi.org/10.1186/s12872-024-04383-zStrokeAtrial fibrillationLeft atrial appendagePercutaneous left atrial appendage closure |
| spellingShingle | Song Zhang Sihuai Xiong Sha Zhang Keyu Chen Hua Wang Ke Li Xudong Xu Xianxian Zhao Ni Zhu Xinmiao Huang Yongwen Qin Zhifu Guo Yuan Bai WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study BMC Cardiovascular Disorders Stroke Atrial fibrillation Left atrial appendage Percutaneous left atrial appendage closure |
| title | WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study |
| title_full | WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study |
| title_fullStr | WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study |
| title_full_unstemmed | WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study |
| title_short | WATCHMAN versus LACbes® device for percutaneous left atrial appendage closure: a single-center, propensity-matched study |
| title_sort | watchman versus lacbes r device for percutaneous left atrial appendage closure a single center propensity matched study |
| topic | Stroke Atrial fibrillation Left atrial appendage Percutaneous left atrial appendage closure |
| url | https://doi.org/10.1186/s12872-024-04383-z |
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