Investigation of a squaramide motif as a bioisostere of the amino-acid group of S-adenosyl-L-methionine and its functional impact on RNA methylation

Investigation of a squaramide motif as a bioisostere of the amino-acid group of S-adenosyl-L-methionine and its functional impact on RNA methylation

Abstract Methyltransferases (MTases) are enzymes that methylate biomolecules like proteins, DNA, RNA, lipids, and small molecules, mostly using S-adenosyl-L-methionine (SAM) as a methyl donor. MTases have emerged as promising drug targets, and SAM analogues are widely employed to investigate their i...

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Main Authors: Jianxun Du, Batoul Mahcene, Valerii Martynov, Elisa Frezza, Christelle Vasnier, Luc Ponchon, Dylan Coelho, Frédéric Bonhomme, Emmanuelle Braud, Mélanie Etheve-Quelquejeu, Bruno Sargueil
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01627-7
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https://doi.org/10.1038/s42004-025-01627-7

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