Elicitation of neutralizing antibodies and IgG4 subclass switching following booster vaccination with ancestral COVID-19 mRNA vaccines does not reduce breakthrough infections

Elicitation of neutralizing antibodies and IgG4 subclass switching following booster vaccination with ancestral COVID-19 mRNA vaccines does not reduce breakthrough infections

Vaccination with COVID-19 mRNA vaccines generates robust antibody responses, but the impact of prior infection on the quality of these responses, particularly immunoglobulin G (IgG) subclass profiles remain unclear. A longitudinal study was conducted to compare humoral immune responses in SARS-CoV-2...

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Bibliographic Details
Main Authors: Engin Berber, Erin E. Jarrett, Hannah B. Hanley, Naoko Uno, Ted M. Ross
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
mRNA vaccine
COVID-19
SARS-CoV-2
virus neutralization
IgG subclass switching
pre-immune
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2025.2547517
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https://www.tandfonline.com/doi/10.1080/21645515.2025.2547517

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