Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways
Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo released by cells and postulated to mediate functions such as intercellular communications. Recent studies have shown that long non-coding RNAs (lncRNAs) or their fragments are present as cargo within EVs. Ln...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041723000045 |
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| author | Michail Spanos Priyanka Gokulnath Emeli Chatterjee Guoping Li Dimitrios Varrias Saumya Das |
| author_facet | Michail Spanos Priyanka Gokulnath Emeli Chatterjee Guoping Li Dimitrios Varrias Saumya Das |
| author_sort | Michail Spanos |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo released by cells and postulated to mediate functions such as intercellular communications. Recent studies have shown that long non-coding RNAs (lncRNAs) or their fragments are present as cargo within EVs. LncRNAs are a heterogeneous group of RNA species with a length exceeding 200 nucleotides with diverse functions in cells based on their localization. While lncRNAs are known for their important functions in cellular regulation, their presence and role in EVs have only recently been explored. While certain studies have observed EV-lncRNAs to be tissue- and disease-specific, it remains to be determined whether or not this is a global observation. Nonetheless, these molecules have demonstrated promising potential to serve as new diagnostic and prognostic biomarkers. In this review, we critically evaluate the role of EV-derived lncRNAs in several prevalent diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases, with a specific focus on their role as biomarkers. |
| format | Article |
| id | doaj-art-c6d0c8dd7ca448a2b7ba8b26f0a1d8dd |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-c6d0c8dd7ca448a2b7ba8b26f0a1d8dd2024-11-23T06:34:52ZengElsevierExtracellular Vesicle2773-04172023-12-012100025Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathwaysMichail Spanos0Priyanka Gokulnath1Emeli Chatterjee2Guoping Li3Dimitrios Varrias4Saumya Das5Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USACardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USACardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USACardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USAAlbert Einstein College of Medicine/Jacobi Medical Center, The Bronx, NY, USACardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Correspondence to: Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo released by cells and postulated to mediate functions such as intercellular communications. Recent studies have shown that long non-coding RNAs (lncRNAs) or their fragments are present as cargo within EVs. LncRNAs are a heterogeneous group of RNA species with a length exceeding 200 nucleotides with diverse functions in cells based on their localization. While lncRNAs are known for their important functions in cellular regulation, their presence and role in EVs have only recently been explored. While certain studies have observed EV-lncRNAs to be tissue- and disease-specific, it remains to be determined whether or not this is a global observation. Nonetheless, these molecules have demonstrated promising potential to serve as new diagnostic and prognostic biomarkers. In this review, we critically evaluate the role of EV-derived lncRNAs in several prevalent diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases, with a specific focus on their role as biomarkers.http://www.sciencedirect.com/science/article/pii/S2773041723000045Extracellular vesiclesLong-noncoding RNACardiovascular diseaseCancerNeurological disease |
| spellingShingle | Michail Spanos Priyanka Gokulnath Emeli Chatterjee Guoping Li Dimitrios Varrias Saumya Das Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways Extracellular Vesicle Extracellular vesicles Long-noncoding RNA Cardiovascular disease Cancer Neurological disease |
| title | Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways |
| title_full | Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways |
| title_fullStr | Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways |
| title_full_unstemmed | Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways |
| title_short | Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways |
| title_sort | expanding the horizon of ev rnas lncrnas in evs as biomarkers for disease pathways |
| topic | Extracellular vesicles Long-noncoding RNA Cardiovascular disease Cancer Neurological disease |
| url | http://www.sciencedirect.com/science/article/pii/S2773041723000045 |
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