Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy

Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy

Background Therapeutic regimens designed to augment the immunological response of a patient with breast cancer (BC) to tumor tissue are critically informed by tumor mutational burden and the antigenicity of expressed neoepitopes. Herein we describe a neoepitope and cognate neoepitope-reactive T-cell...

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Main Authors: Jeffrey Schlom, James L Gulley, Andrew Nguyen, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong, Duane H Hamilton, Marieke Griffioen, Andreas Mackensen, Stephen C Benz, Patricia Spilman, Peter A Fasching, Matthias W Beckmann, Alexander Hein, Matthias Ruebner, Hannah Reimann, J Zachary Sanborn, Charles J Vaske, Edith D van der Meijden, Judith Bausenwein, Sascha Kretschmann, Karin L Lee, Anita N. Kremer
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/6/e002605.full
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