IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa

IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa

Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, which is universally expressed and IRE1β, which shows specific expression within mucus secreted cells in respiratory a...

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Bibliographic Details
Main Authors: Hui Luo, Wen-Yan Gong, Yuan-Yuan Zhang, Ying-Ying Liu, Zhen Chen, Xing-Lin Feng, Qi-Bin Jiao, Xing-Wei Zhang
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
Unfolded protein response
Evolutionary conservation
IRE1α
IRE1β
Mucosal homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024150426
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