A mucus layer derived from porcine intestinal organoid air–liquid interface monolayer attenuates swine enteric coronavirus infection by antiviral activity of Muc2

A mucus layer derived from porcine intestinal organoid air–liquid interface monolayer attenuates swine enteric coronavirus infection by antiviral activity of Muc2

Abstract Background The mucus layer provides the first defense that keeps the epithelium free from microorganisms. However, the effect of the small intestinal mucus layer on pathogen invasion is still poorly understood, especially for swine enteric coronavirus. To better understand virus‒mucus layer...

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Bibliographic Details
Main Authors: Ning Yang, Yang Li, Yifei Cai, Yuanyuan Liu, Yunhang Zhang, Yuguang Fu, Chen Tan, Luc Willems, Guangliang Liu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Biology
Subjects:
Coronavirus
Intestinal organoid monolayer
Air‒liquid interface (ALI)
Mucus layer
Muc2
Sialic acid
Online Access:https://doi.org/10.1186/s12915-024-02094-7
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https://doi.org/10.1186/s12915-024-02094-7

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