IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways

IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways

Abstract The development and progression of liver cirrhosis are considerably influenced by immune processes, with CD8 + T cells playing a key role. Notably, cytokines can activate bystander CD38 + HLA-DR + CD8 + T cells without the need for T cell receptor (TCR) stimulation. However, their role in l...

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Bibliographic Details
Main Authors: Ke Liu, Hongliang Dong, Kaiyue Zhang, Wanping Yan, Huanyu Wu, Jing fan, Wei Ye
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Liver cirrhosis
CD8+ T cell
TCR
Bystander activation
IL-15
Online Access:https://doi.org/10.1038/s41598-025-02693-6
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https://doi.org/10.1038/s41598-025-02693-6

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