Simulated microgravity accurately models long-duration spaceflight effects on bone and skeletal muscle in skeletally immature mice

Simulated microgravity accurately models long-duration spaceflight effects on bone and skeletal muscle in skeletally immature mice

Spaceflight (SF) and disuse result in decreases in bone and skeletal muscle volume that increase fracture risk. Hindlimb unloading (HLU) has been widely used to model the effects of microgravity. However, the effects of SF and HLU on bone and skeletal muscle have not been directly compared during lo...

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Bibliographic Details
Main Authors: Michael A. Friedman, Yasmina Zeineddine, Olivier Tuyambaze, Wesam Elhawabri, Ahmed Al Shammary, Louis Stodieck, Virginia L. Ferguson, Henry J. Donahue
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Bone Reports
Subjects:
Spaceflight
Bone
Skeletal muscle
Animal model
Hindlimb unloading
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187225000488
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