Impact of cell culture transition on adipose-derived mesenchymal stromal cells: Multi-omics analysis of small- vs large-scale production

Impact of cell culture transition on adipose-derived mesenchymal stromal cells: Multi-omics analysis of small- vs large-scale production

Mesenchymal stromal cells (MSCs) are being tested in numerous clinical trials, yet the limited progression of these trials to advanced stages indicates unresolved translational challenges. Expanding MSCs is a critical step in most therapeutic applications, and bioreactor-based culture offers large-s...

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Bibliographic Details
Main Authors: Marina Ramírez Galera, Athanasios Oikonomou, Jonas D. Elsborg, Lisa Harth, Anne Fischer-Nielsen, Marianne Bengtson Løvendorf, Beatrice Dyring-Andersen, Francesco Iorio, Lea Munthe Fog, Anders Woetmann, Jesper Dyrendom Svalgaard
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adipose-derived mesenchymal stromal cells
AD-MSCs
MSCs
cell expansion
large-scale cell production
bioreactor
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012500107X
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