Altered Pharmacokinetics of Ropivacaine in Patients Undergoing Laparoscopic Major Hepatectomy

Altered Pharmacokinetics of Ropivacaine in Patients Undergoing Laparoscopic Major Hepatectomy

<b>Background/Objectives:</b> Ropivacaine is primarily metabolized by the liver. High doses of ropivacaine, combined with altered pharmacokinetics due to hepatectomy, raise concerns about potential drug toxicity. We investigated the impact of LMH (laparoscopic major hepatectomy) on the p...

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Bibliographic Details
Main Authors: Jun Zhang, Hongyuan Lv, Jiliang Shen, Zhichao Ai, Minjun Liu, Xiaorui Liu, Tieshuai Liu, Bo Shen, Hong Yu, Xin Yu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
alpha-1 acid glycoprotein
bilateral dual transversus abdominis plane block
laparoscopic major hepatectomy
local anesthetic toxicity
ropivacaine
Online Access:https://www.mdpi.com/1999-4923/17/3/386
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