A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies

A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies

Summary: Antibodies that target the gp120-gp41 interface of the HIV-1 envelope (Env) trimer comprise a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate and characterize VRC44, a bNAb lineage with up to 52% neutralization breadth. The cryoelectron microscopy (cr...

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Main Authors: Evan M. Cale, Chen-Hsiang Shen, Adam S. Olia, Nathan A. Radakovich, Reda Rawi, Yongping Yang, David R. Ambrozak, Anthony K. Bennici, Gwo-Yu Chuang, Emma D. Crooks, Jefferson I. Driscoll, Bob C. Lin, Mark K. Louder, Patrick J. Madden, Michael A. Messina, Keiko Osawa, Guillaume B.E. Stewart-Jones, Raffaello Verardi, Zoe Vrakas, Danielle Xie, Baoshan Zhang, James M. Binley, Mark Connors, Richard A. Koup, Theodore C. Pierson, Nicole A. Doria-Rose, Peter D. Kwong, John R. Mascola, Jason Gorman
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013615
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