Zollinger-Ellison syndrome. Case report
Introduction: The Zollinger-Ellison syndrome (ZES) is a pathology caused by a neuroendocrine tumor, usually located in the pancreas or the duodenum, which is characterized by elevated levels of gastrin, resulting in an excessive production of gastric acid. Case presentation: A 42-year-old female p...
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Universidad Nacional de Colombia
2019-01-01
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| Online Access: | https://revistas.unal.edu.co/index.php/care/article/view/71686 |
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| author | Juan Felipe Rivillas-Reyes Juan Leonel Castro-Avendaño Héctor Fabián Martínez-Muñoz |
| author_facet | Juan Felipe Rivillas-Reyes Juan Leonel Castro-Avendaño Héctor Fabián Martínez-Muñoz |
| author_sort | Juan Felipe Rivillas-Reyes |
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Introduction: The Zollinger-Ellison syndrome (ZES) is a pathology caused by a neuroendocrine tumor, usually located in the pancreas or the duodenum, which is characterized by elevated levels of gastrin, resulting in an excessive production of gastric acid.
Case presentation: A 42-year-old female patient with a history of longstanding peptic ulcer disease, who consulted due to persistent epigastric pain, melena and signs of peritoneal irritation. Perforated peptic ulcer was suspected, requiring emergency surgical intervention. Subsequently, a tumor lesion in the head of the pancreas was documented and managed with Whipple procedure. The pathology results reported a tumor suggestive of neuroendocrine neoplasm.
Discussion: The Zollinger-Ellison syndrome occurs in 0.1 to 3 people per 1 000 000 inhabitants worldwide and is predominant in women between 20 and 50 years of age. It usually appears as a refractory acid-peptic disease or as a complication of gastric acid hypersecretion. Medical therapy is the standard management, being proton pump inhibitors (PPI) the most effective option. Surgery is recommended for sporadic ZES.
Conclusions: ZES has a low incidence rate. It is rarely considered in the differential diagnosis of chronic epigastric pain and high clinical suspicion is required to achieve adequate management. This article is highly relevant as it presents a confirmed clinical case of ZES in Colombia, highlighting the importance of producing local scientific literature to improve the diagnosis and treatment of this pathology.
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| format | Article |
| id | doaj-art-c5babde21a3d4277896ca5d252fdf4fe |
| institution | Kabale University |
| issn | 2462-8522 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Universidad Nacional de Colombia |
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| series | Case Reports |
| spelling | doaj-art-c5babde21a3d4277896ca5d252fdf4fe2024-11-26T23:59:26ZengUniversidad Nacional de ColombiaCase Reports2462-85222019-01-015110.15446/cr.v5n1.7168650171Zollinger-Ellison syndrome. Case reportJuan Felipe Rivillas-Reyes0Juan Leonel Castro-Avendaño1Héctor Fabián Martínez-Muñoz2Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Programa de MedicinaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Programa de MedicinaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Departamento de Cirugía Introduction: The Zollinger-Ellison syndrome (ZES) is a pathology caused by a neuroendocrine tumor, usually located in the pancreas or the duodenum, which is characterized by elevated levels of gastrin, resulting in an excessive production of gastric acid. Case presentation: A 42-year-old female patient with a history of longstanding peptic ulcer disease, who consulted due to persistent epigastric pain, melena and signs of peritoneal irritation. Perforated peptic ulcer was suspected, requiring emergency surgical intervention. Subsequently, a tumor lesion in the head of the pancreas was documented and managed with Whipple procedure. The pathology results reported a tumor suggestive of neuroendocrine neoplasm. Discussion: The Zollinger-Ellison syndrome occurs in 0.1 to 3 people per 1 000 000 inhabitants worldwide and is predominant in women between 20 and 50 years of age. It usually appears as a refractory acid-peptic disease or as a complication of gastric acid hypersecretion. Medical therapy is the standard management, being proton pump inhibitors (PPI) the most effective option. Surgery is recommended for sporadic ZES. Conclusions: ZES has a low incidence rate. It is rarely considered in the differential diagnosis of chronic epigastric pain and high clinical suspicion is required to achieve adequate management. This article is highly relevant as it presents a confirmed clinical case of ZES in Colombia, highlighting the importance of producing local scientific literature to improve the diagnosis and treatment of this pathology. https://revistas.unal.edu.co/index.php/care/article/view/71686GastrinomaZollinger-Ellison SydromeMultiple Endocrine Neoplasia Type 1. |
| spellingShingle | Juan Felipe Rivillas-Reyes Juan Leonel Castro-Avendaño Héctor Fabián Martínez-Muñoz Zollinger-Ellison syndrome. Case report Case Reports Gastrinoma Zollinger-Ellison Sydrome Multiple Endocrine Neoplasia Type 1. |
| title | Zollinger-Ellison syndrome. Case report |
| title_full | Zollinger-Ellison syndrome. Case report |
| title_fullStr | Zollinger-Ellison syndrome. Case report |
| title_full_unstemmed | Zollinger-Ellison syndrome. Case report |
| title_short | Zollinger-Ellison syndrome. Case report |
| title_sort | zollinger ellison syndrome case report |
| topic | Gastrinoma Zollinger-Ellison Sydrome Multiple Endocrine Neoplasia Type 1. |
| url | https://revistas.unal.edu.co/index.php/care/article/view/71686 |
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