Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation

Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation

Abstract Sorafenib, a multikinase inhibitor targeting cell growth and angiogenesis, was approved for advanced unresectable hepatocellular carcinoma (HCC) in 2007. This investigation aims to elucidate the involvement of aquaglyceroporin-7 (AQP7) in regulating sorafenib resistance (SR) in HCC. AQP7 wa...

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Bibliographic Details
Main Authors: Guangsi He, Wenzhu Shao, Weifei Wang, Lu Sun, Beibei Gao, Jie Wei
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Orthotopic tumors
Ubiquitination
Tumor microenvironment
Chemoresistance
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Online Access:https://doi.org/10.1007/s00018-025-05801-x
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https://doi.org/10.1007/s00018-025-05801-x

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