Low, but Not High, Pulsating Fluid Shear Stress Affects Matrix Extracellular Phosphoglycoprotein Expression, Mainly via Integrin β Subunits in Pre-Osteoblasts

Low, but Not High, Pulsating Fluid Shear Stress Affects Matrix Extracellular Phosphoglycoprotein Expression, Mainly via Integrin β Subunits in Pre-Osteoblasts

Matrix extracellular phosphoglycoprotein (Mepe), present in bone and dentin, plays important multifunctional roles in cell signaling, bone mineralization, and phosphate homeostasis. Mepe expression in bone cells changes in response to pulsating fluid shear stress (PFSS), which is transmitted into ce...

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Bibliographic Details
Main Authors: Jianfeng Jin, Behrouz Zandieh-Doulabi
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Current Issues in Molecular Biology
Subjects:
integrin α/β subunit
matrix extracellular phosphoglycoprotein
mechanical loading
osteogenic differentiation
pre-osteoblasts
pulsating fluid shear stress
Online Access:https://www.mdpi.com/1467-3045/46/11/738
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