Rapid generation of a sdhb loss-of-function zebrafish model for secreting pheochromocytomas and paragangliomas

Rapid generation of a sdhb loss-of-function zebrafish model for secreting pheochromocytomas and paragangliomas

Abstract Genotype plays a central role in the comprehensive management of pheochromocytomas and paragangliomas, highlighting the critical need for specific in vivo genetic models. Yet, animal models fall short of fully recapitulating the biological complexity of these tumours. We generated first-gen...

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Main Authors: S. Parisien-La Salle, F. Nobilleau, A. da Silva Babinet, J. Lamontagne, M. Labrecque, B. Rampal, C. Mas, M. Liao, V. A. Barragan Torres, G. Corbeil, L. Chatel-Chaix, M. Dona, M. Tétreault, I. Bourdeau, É. Samarut
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-025-00518-z
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https://doi.org/10.1038/s41525-025-00518-z

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