METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance

METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance

Abstract Background Non-small-cell lung cancer (NSCLC) is a highly aggressive cancer with a poor prognosis, largely due to increasing resistance to Tyrosine Kinase Inhibitors (TKIs). The mechanisms of NSCLC TKI resistance remain unknown. This study aimed to elucidate the molecular mechanism of METTL...

Full description

Saved in:
Bibliographic Details
Main Authors: Yingou Zeng, Qiang Wang, Di Qiao, Bin Dai, Yunlong Wu, Meng Wang, Zhe Fan, Jia Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
NSCLC
Proliferation
GPX4
Ferroptosis
AZD-9291 resistance
Online Access:https://doi.org/10.1186/s12885-025-14729-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12885-025-14729-1

Similar Items