Design, synthesis, in vitro, and in silico studies of 4-fluorocinnamaldehyde based thiosemicarbazones as urease inhibitors

Design, synthesis, in vitro, and in silico studies of 4-fluorocinnamaldehyde based thiosemicarbazones as urease inhibitors

Abstract Clinically significant problems such as kidney stones and stomach ulcers are linked to the activation of the urease enzyme. At low pH, this enzyme gives an ideal environment to Helicobacter pylori in the stomach which is the cause of gastric ulcers and peptic ulcers. In recent work, we have...

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Main Authors: Muhammad Islam, Saeed Ullah, Ajmal Khan, Zahra Batool, Suraj N. Mali, Shailesh S. Gurav, Kholood A. Dahlous, Saikh Mohammad, Javid Hussain, Ahmed Al-Harrasi, Zahid Shafiq
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Thiosemicarbazones
4-fluorocinnamaldehyde
Urease inhibition
Docking
ADME
FMO
Online Access:https://doi.org/10.1038/s41598-024-83386-4
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https://doi.org/10.1038/s41598-024-83386-4

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