Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey
BackgroundThe relationship between serum total bilirubin (STB) concentrations and the risk of overactive bladder (OAB) remains uncertain. This study aims to explore the potential connection between STB and OAB.MethodWe utilized data from the National Health and Nutrition Examination Survey (NHANES)...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1421426/full |
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| author | Bo Jiang Bo Jiang Bo Jiang Cunbao Ling Binbin Dong Binbin Dong Xiaoming Lu Xiaoming Lu Yadong Liu Yadong Liu Yadong Liu |
| author_facet | Bo Jiang Bo Jiang Bo Jiang Cunbao Ling Binbin Dong Binbin Dong Xiaoming Lu Xiaoming Lu Yadong Liu Yadong Liu Yadong Liu |
| author_sort | Bo Jiang |
| collection | DOAJ |
| description | BackgroundThe relationship between serum total bilirubin (STB) concentrations and the risk of overactive bladder (OAB) remains uncertain. This study aims to explore the potential connection between STB and OAB.MethodWe utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2001-2020. Weighted multivariate logistic regression and restricted cubic spline (RCS) analysis assessed the relationship between STB and OAB. Interaction analyses on subgroups were performed to validate the findings.ResultsThe study included 28,958 participants, with 5,313 identified as having OAB. The results from the fully adjusted models revealed an odds ratio (OR) of 0.98 (95% CI: 0.97, 0.99) and a statistically significant P value of less than 0.001 for the relationship between STB and OAB. Notably, individuals in the second and third tertiles exhibited significant differences compared to those in the lowest STB tertile, with respective odds ratios (P values) of 0.88 (0.04) and 0.80 (<0.001). RCS analysis indicated a non-linear association between STB and OAB (P for nonlinearity = 0.042), with an inflection point at 16.8 μmol/L. The association between STB and OAB exhibited consistency across various subgroups, except for stratification by age and diabetes status(P for interaction = 0.002 and 0.004, respectively), indicating a stronger correlation in individuals younger than 60 years or those without diabetes.ConclusionThese findings suggest an inverse association between STB concentrations below 16.8 μmol/L and the incidence of OAB. Bilirubin could potentially serve as an intervention or risk assessment tool for OAB in future studies. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-c4f8134a887645b484b7f2af6c08c05d2025-01-14T05:10:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14214261421426Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination SurveyBo Jiang0Bo Jiang1Bo Jiang2Cunbao Ling3Binbin Dong4Binbin Dong5Xiaoming Lu6Xiaoming Lu7Yadong Liu8Yadong Liu9Yadong Liu10Department of Urology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, ChinaDepartment of Urology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, ChinaDepartment of Urology, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaSchool of Basic Medical Sciences, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu, ChinaDepartment of Urology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, ChinaDepartment of Urology, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaDepartment of Urology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, ChinaDepartment of Urology, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaDepartment of Urology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, ChinaDepartment of Urology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, ChinaDepartment of Urology, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaBackgroundThe relationship between serum total bilirubin (STB) concentrations and the risk of overactive bladder (OAB) remains uncertain. This study aims to explore the potential connection between STB and OAB.MethodWe utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2001-2020. Weighted multivariate logistic regression and restricted cubic spline (RCS) analysis assessed the relationship between STB and OAB. Interaction analyses on subgroups were performed to validate the findings.ResultsThe study included 28,958 participants, with 5,313 identified as having OAB. The results from the fully adjusted models revealed an odds ratio (OR) of 0.98 (95% CI: 0.97, 0.99) and a statistically significant P value of less than 0.001 for the relationship between STB and OAB. Notably, individuals in the second and third tertiles exhibited significant differences compared to those in the lowest STB tertile, with respective odds ratios (P values) of 0.88 (0.04) and 0.80 (<0.001). RCS analysis indicated a non-linear association between STB and OAB (P for nonlinearity = 0.042), with an inflection point at 16.8 μmol/L. The association between STB and OAB exhibited consistency across various subgroups, except for stratification by age and diabetes status(P for interaction = 0.002 and 0.004, respectively), indicating a stronger correlation in individuals younger than 60 years or those without diabetes.ConclusionThese findings suggest an inverse association between STB concentrations below 16.8 μmol/L and the incidence of OAB. Bilirubin could potentially serve as an intervention or risk assessment tool for OAB in future studies.https://www.frontiersin.org/articles/10.3389/fendo.2024.1421426/fulloveractive bladderserum total bilirubina population-based studyrisk assessmentNHANES |
| spellingShingle | Bo Jiang Bo Jiang Bo Jiang Cunbao Ling Binbin Dong Binbin Dong Xiaoming Lu Xiaoming Lu Yadong Liu Yadong Liu Yadong Liu Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey Frontiers in Endocrinology overactive bladder serum total bilirubin a population-based study risk assessment NHANES |
| title | Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey |
| title_full | Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey |
| title_fullStr | Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey |
| title_full_unstemmed | Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey |
| title_short | Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey |
| title_sort | associations between serum total bilirubin and overactive bladder from the national health and nutrition examination survey |
| topic | overactive bladder serum total bilirubin a population-based study risk assessment NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1421426/full |
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